Does Holden annihilate others, or do they annihilate him?

Annihilate means to completely destroy.  I don't think that Holden annihilates anybody.  He is too much of an anti-social loner.  He does try to interact with people throughout the novel, but he is always so frustrated by them, that he walks away.  He's never around long enough for anybody to annihilate him either.  Plus he's never destroyed.  He starts and ends the story basically the same way.  

I think perhaps you meant "alienate" instead...

Annihilate means to completely destroy.  I don't think that Holden annihilates anybody.  He is too much of an anti-social loner.  He does try to interact with people throughout the novel, but he is always so frustrated by them, that he walks away.  He's never around long enough for anybody to annihilate him either.  Plus he's never destroyed.  He starts and ends the story basically the same way.  

I think perhaps you meant "alienate" instead of annihilate.  If that's the case, I think Holden alienates others.  There are times throughout the story that people reach out to Holden and try to help him.  For example, Mr. Spencer clearly wants to help Holden get out of his academic apathy.  The problem is that Holden wants nothing to do with that kind of encouragement, so he walks away.  Stradlater is another character that I think could actually be friends with Holden.  When the two boys get into a fight, it's clear that Stradlater doesn't want to hurt Holden.  If Stradlater did't care about Holden or hated him, he wouldn't have a problem pummeling Holden.  But he doesn't beat Holden to a pulp. But once again Holden walks away from a potential friendship believing that Stradlater is just another phony.  People are constantly around Holden and don't mistreat him.  Yet Holden distances himself time and time again. Holden alienates others away from him.